Tissue and cellular biomechanics during corneal wound injury and repair
نویسندگان
چکیده
منابع مشابه
Tissue and cellular approaches to wound repair.
Tissue engineering can be defined as the use of biomaterials with or without small molecules, cells, genes, or gene products to maintain, replace, or repair organ function with the objective of correcting the underlying pathology. This new field of medicine is based on the use of engineered cells, tissues, and synthetic materials that can potentially extend and improve a patient’s life. At the ...
متن کاملCellular migration and morphology in corneal endothelial wound repair.
After a mechanical denudation of rabbit corneal endothelial cells, the healing process was followed with wide-field specular microscopy. Individual cell migration and morphologic changes were analyzed by computer-assisted morphometry. The cells surrounding the wound migrated to cover the defect without producing intercellular gaps. The greatest cellular migration and morphologic alterations occ...
متن کاملMembrane dynamics during cellular wound repair
Cells rapidly reseal after damage, but how they do so is unknown. It has been hypothesized that resealing occurs due to formation of a patch derived from rapid fusion of intracellular compartments at the wound site. However, patching has never been directly visualized. Here we study membrane dynamics in wounded Xenopus laevis oocytes at high spatiotemporal resolution. Consistent with the patch ...
متن کاملProtein kinase C activation during corneal endothelial wound repair.
In previous studies, the authors have shown that the two forms of cell translocation that occur during corneal endothelial monolayer wound repair can be pharmacologically separated. Epidermal growth factor (EGF) enhanced the breaking of cell-cell contacts and movement of individual cells from the wound edge, while indomethacin, an inhibitor of PGE2 synthesis, promoted cell enlargement and sprea...
متن کاملDesigning hydrogel adhesives for corneal wound repair.
Today, corneal wounds are repaired using nylon sutures. Yet there are a number of complications associated with suturing the cornea, and thus there is interest in an adhesive to replace or supplement sutures in the repair of corneal wounds. We are designing and evaluating corneal adhesives prepared from dendrimers--single molecular weight and highly branched polymers. We have explored two strat...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2017
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2017.05.051